More than 45,000 viruses infect PCs running the Windows operating system worldwide. Several have caused billions of dollars in damage in the past 12 months. Hundreds more viruses appear each year, requiring armies of anti-virus programmers to isolate and kill the offending bugs. By contrast, perhaps 35 viruses have been written for the Macintosh and four or five for the Unix-based computers that run most Web sites, says Eugene Spafford, director of the Computer Operations, Audit and Security Technology lab at Purdue University. This, a growing chorus of security experts say, is not happenstance